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Mafia: Definitive Edition is a 2020 action-adventure game developed by Hangar 13 and published by 2K. It is a remake of the 2002 video game Mafia and the fourth entry in the series. Like the original game, the remake is set within the fictional city of Lost Heaven, Illinois, during the 1930s, and follows the rise and fall of Tommy Angelo, a Sicilian American cab driver-turned-gangster, within the Salieri crime family.

OXGR1, i.e., 2-oxoglutarate receptor 1 is a G protein-coupled receptor located on the surface membranes of certain cells. It functions by binding one of its ligands and thereby becoming active in triggering pre-programmed responses in its parent cells. OXGR1 has been shown to be activated by α-ketoglutarate, itaconate, and three cysteinyl-containing leukotrienes, leukotriene E4, LTC4, and LTD4. α-Ketoglutarate and itaconate are the dianionic forms of α-ketoglutaric acid and itaconic acid, respectively. α-Ketoglutaric and itaconic acids are short-chain dicarboxylic acids that have two carboxyl groups both of which are bound to hydrogen. However, at the basic pH levels in virtually all animal tissues, α-ketoglutaric acid and itaconic acid exit almost exclusively as α-ketoglutarate and itaconate, i.e., with their carboxy residues being negatively charged, because they are not bound to H⁺. It is α-ketoglutarate and itaconate, not α-ketoglutaric or itaconic acids, which activate OXGR1.